Reconstructing the Differentiation Niche of Embryonic Stem Cells Using Biomaterials

被引：59

作者：

Dickinson, Laura E. ^{[1
,2
]}

Kusuma, Sravanti ^{[1
,2
,3
]}

Gerecht, Sharon ^{[1
,2
]}

机构：

[1] Johns Hopkins Phys Sci Oncol Ctr, Dept Chem & Biomol Engn, Baltimore, MD 21210 USA

[2] Inst NanoBioTechnol, Baltimore, MD 21210 USA

[3] Johns Hopkins Univ, Baltimore, MD 21218 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 01期

关键词：

biocompatibility; biological application of polymers; biomaterials; nanotechnology; NANO-STRUCTURED SURFACES; EXTRACELLULAR-MATRIX; IN-VITRO; CHONDROGENIC DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; HEPATIC DIFFERENTIATION; GROWTH-FACTORS; 3-DIMENSIONAL CULTURE; VASCULAR DEVELOPMENT; HYALURONIC-ACID;

D O I：

10.1002/mabi.201000245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The biochemical cues and topographical architecture of the extracellular environment extensively influence ES cell fate. The microenvironment surrounding the developing embryo presents these instructive cues in a complex and interactive manner in order to guide cell fate decisions. Current stem cell research aims to reconstruct this multifaceted embryonic niche to recapitulate development in vitro. This review focuses on 2D and 3D differentiation niches created from natural and synthetic biomaterials to guide the differentiation of ES cells toward specific lineages. Biomaterials engineered to present specific physical constraints are also reviewed for their role in differentiation.

引用

页码：36 / 49

页数：14

共 177 条

[1]

Bio-electrospraying embryonic stem cells: interrogating cellular viability and pluripotency [J].

Abeyewickreme, Anil ;

Kwok, Albert ;

McEwan, Jean R. ;

Jayasinghe, Suwan N. .

INTEGRATIVE BIOLOGY, 2009, 1 (03) :260-266

[2]

AOTA S, 1994, J BIOL CHEM, V269, P24756

[3]

Aerodynamically assisted jetting and threading for processing concentrated suspensions containing advanced structural, functional and biological materials [J].

Arumuganathar, Sumathy ;

Suter, Nicolai ;

Walzel, Peter ;

Jayasinghe, Suwan N. .

Biotechnology Journal, 2009, 4 (01) :64-72

[4]

Alginate hydrogels as biomaterials [J].

Augst, Alexander D. ;

Kong, Hyun Joon ;

Mooney, David J. .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (08) :623-633

[5]

The effect of extracellular matrix on embryonic stem cell-derived cardiomyocytes [J].

Baharvand, H ;

Azarnia, M ;

Parivar, K ;

Ashtiani, SK .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 38 (03) :495-503

[6]

Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro [J].

Baharvand, Hossein ;

Hashemi, Seyed M. ;

Kazemi Ashtian, Saeid ;

Farrokhi, Ali .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2006, 50 (07) :645-652

[7]

The differentiation and engraftment potential of mouse hematopoietic stem cells is maintained after bio-electrospray [J].

Bartolovic, Kerol ;

Mongkoldhumrongkul, Napachanok ;

Waddington, Simon N. ;

Jayasinghe, Suwan N. ;

Howe, Steven J. .

ANALYST, 2010, 135 (01) :157-164

[8]

The effect of matrix composition of 3D constructs on embryonic stem cell differentiation [J].

Battista, S ;

Guarnieri, D ;

Borselli, C ;

Zeppetelli, S ;

Borzacchiello, A ;

Mayol, L ;

Gerbasio, D ;

Keene, DR ;

Ambrosio, L ;

Netti, PA .

BIOMATERIALS, 2005, 26 (31) :6194-6207

[9]

Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories [J].

Bauwens, Celine Liu ;

Peerani, Raheem ;

Niebruegge, Sylvia ;

Woodhouse, Kimberly A. ;

Kumacheva, Eugenia ;

Husain, Mansoor ;

Zandstra, Peter W. .

STEM CELLS, 2008, 26 (09) :2300-2310

[10]

Enhancement of in vitro capillary tube formation by substrate nanotopography [J].

Bettinger, Christopher J. ;

Zhang, Zhitong ;

Gerecht, Sharon ;

Borenstein, Jeffrey T. ;

Langer, Robert .

ADVANCED MATERIALS, 2008, 20 (01) :99-+

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