Enhancement of in vitro capillary tube formation by substrate nanotopography

被引：129

作者：

Bettinger, Christopher J. ^{[1
,3
]}

Zhang, Zhitong ^{[2
]}

Gerecht, Sharon ^{[4
]}

Borenstein, Jeffrey T. ^{[1
]}

Langer, Robert ^{[2
]}

机构：

[1] Charles Stark Draper Lab Inc, Biomed Engn Ctr, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[4] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 01期

关键词：

D O I：

10.1002/adma.200702487

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Endothelial progenitor cells are cultured on nanotopographic substrates with a line-grating geometry and respond to these substrates through aligned and elongated morphology, reduced proliferation, and increased migration relative to flat substrates. The cells also form supercellular band structures, which lead to enhanced capillary tube formation upon the addition of matrigel. These results suggest that substrate nanotopography can be used to create organized vascular structures in vitro. Image taken at 250 x magnification.

引用

页码：99 / +

页数：6

共 34 条

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