Molecular ultrasound imaging using microbubble contrast agents

被引：106

作者：

Dayton, Paul A. ^{[1
]}

Rychak, Joshua J. ^{[2
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

[2] Univ Virginia, Cardiovasc Res Ctr, Charlottesville, VA 22903 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2007年 / 12卷

关键词：

ultrasound; microbubble; targeted imaging; molecular Imaging; review; GAS-FILLED MICROBUBBLES; IN-VIVO; RADIATION FORCE; THERAPEUTIC APPLICATIONS; ALBUMIN MICROBUBBLE; P-SELECTIN; LYMPHOCYTE-RECIRCULATION; ADHESION MOLECULES; TUMOR ANGIOGENESIS; TARGETED DELIVERY;

D O I：

10.2741/2553

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular imaging is a new field in bioscience which, by virtue of utilizing a contrast agent or reporter, facilitates early detection of the disease processes before phenotypic changes become apparent. Molecular imaging with ultrasound utilizes contrast agents that bear adhesion ligands designed to bind tissue markers specific for a disease process. Such agents can be detected by ultrasound with a great degree of sensitivity, providing both anatomical reference information as well as additional data such as molecular characteristics of the interrogated region. This review summarizes current applications and challenges of molecular ultrasound imaging and offers future technologies which likely follow as an improvement to the existing techniques. Due to the widespread availability of ultrasound and ease of use, molecular ultrasound imaging is likely to emerge as a powerful diagnostic technique.

引用

页码：5124 / 5142

页数：19

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