XCI in preimplantation mouse and human embryos: first there is remodelling ...

被引：24

作者：

van den Berg, I. M. ^{[1
,2
]}

Galjaard, R. J. ^{[2
]}

Laven, J. S. E. ^{[1
]}

van Doorninck, J. H. ^{[1
,2
]}

机构：

[1] Erasmus MC, Subdiv Reprod Med, Dept Obstet & Gynecol, Rotterdam, Netherlands

[2] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

来源：

HUMAN GENETICS | 2011年 / 130卷 / 02期

关键词：

X-CHROMOSOME INACTIVATION; IMPRINTED XIST EXPRESSION; LINKED GENE-EXPRESSION; IN-VITRO CULTURE; STEM-CELLS; DOSAGE COMPENSATION; CHORIONIC VILLI; EXTRAEMBRYONIC TISSUES; HISTONE MACROH2A1; HUMAN-PLACENTA;

D O I：

10.1007/s00439-011-1014-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Female eutherians silence one of their X chromosomes to accomplish an equal dose of X-linked gene expression compared with males. The mouse is the most widely used animal model in XCI research and has proven to be of great significance for understanding the complex mechanism of X-linked dosage compensation. Although the basic principles of XCI are similar in mouse and humans, differences exist in the timing of XCI initiation, the genetic elements involved in XCI regulation and the form of XCI in specific tissues. Therefore, the mouse has its limitations as a model to understand early human XCI and analysis of human tissues is required. In this review, we describe these differences with respect to initiation of XCI in human and mouse preimplantation embryos, the extra-embryonic tissues and the in vitro model of the epiblast: the embryonic stem cells.

引用

页码：203 / 215

页数：13

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