Needle-free skin patch vaccination method for anthrax

被引：41

作者：

Matyas, GR

Friedlander, AM

Glenn, GM

Little, S

Yu, JM

Alving, CR

机构：

[1] Walter Reed Army Inst Res, Dept Membrane Biochem, Silver Spring, MD 20910 USA

[2] Iomai Corp, Gaithersburg, MD 20878 USA

[3] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 02期

关键词：

D O I：

10.1128/IAI.72.2.1181-1183.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.

引用

页码：1181 / 1183

页数：3

共 13 条

[1]

[Anonymous], 2002, ANTHRAX VACCINE IS I

[2] Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin [J].