Siglecs, sialic acids and innate immunity

被引：316

作者：

Crocker, PR ^{[1
]}

Varki, A

机构：

[1] Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Dundee DD1 5EH, Scotland

[2] Univ Calif San Diego, Dept Med, Glycobiol Res & Training Ctr, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Ctr Canc, La Jolla, CA 92093 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 06期

关键词：

D O I：

10.1016/S1471-4906(01)01930-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Siglecs are members of the Ig superfamily that bind to sialic acid (Sia) and are mainly expressed by cells of the hematopoietic system. Until three years ago, only four Siglecs were known, namely sialoadhesin. CD22, myelin-associated glycoprotein and CD33. Since then, a further six human CD33-related Siglecs with features of inhibitory receptors have been identified and shown to be expressed by discrete subsets of leukocytes. Recognition of Sia by these Siglecs could play a role in the regulation of the innate immune system.

引用

页码：337 / 342

页数：6

共 53 条

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