Reprogramming a Broken Heart

被引：10

作者：

Hansson, Emil M. ^{[1
,2
]}

Chien, Kenneth R. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 01238 USA

[2] MGH Cardiovasc Res Ctr, Boston, MA 02114 USA

来源：

CELL STEM CELL | 2012年 / 11卷 / 01期

关键词：

FIBROBLASTS; CARDIOMYOCYTES; MYOCYTES;

D O I：

10.1016/j.stem.2012.06.014

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Fibrosis resulting from cardiac injury presents a major challenge to restoring heart function after myocardial infarction. Two recent papers in Nature report successful in vivo reprogramming of fibroblasts to cardiomyocytes in injured mouse hearts (Qian et al., 2012; Song et al., 2012), resulting in improved cardiac function and reduced scar formation.

引用

页码：3 / 4

页数：2

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