Virulence determinants in community and hospital meticillin-resistant Staphylococcus aureus

被引：87

作者：

Tristan, Anne ^{[1
]}

Ferry, Tristan ^{[1
]}

Durand, Geraldine ^{[1
]}

Dauwalder, Olivier ^{[1
]}

Bes, Michele ^{[1
]}

Lina, Gerard ^{[1
]}

Vandenesch, Francois ^{[1
]}

Etienne, Jerome ^{[1
]}

机构：

[1] Univ Lyon 1, Fac Med Laennec, INSERM E0230, Ctr Natl Reference Staphylocoques, F-69008 Lyon, France

来源：

JOURNAL OF HOSPITAL INFECTION | 2007年 / 65卷

关键词：

Staphylococcus aureus; virulence factors; superantigenic toxins; Panton Valentine leukocidin; meticillin resistance;

D O I：

10.1016/S0195-6701(07)60025-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Staphylococcus aureus produces many virulence factors, most of which act in a synergistic and coordinated fashion. Some appear to be specifically associated with certain severe infections and are produced by meticillin-resistant Staphylococcus aureus (MRSA) clones distributed worldwide. Superantigenic exotoxins appear to be major virulence factors in hospital MRSA clones (HA-MRSA), and staphylococcal enterotoxin A (SEA) may be involved in the physiopathology of septic shock. Panton Valentine Leucocidin (PVL) has emerged as a major virulence factor in community-acquired Staphylococcus aureus (CA-MRSA) infections. In particular, the Leukotoxic action of PVL is responsible for the high mortality rate associated with necrotizing pneumonia. CA-MRSA can also harbour the toxic shock toxin 1 (TSST-1) and rarely the exfoliative toxin. (C) 2007 The Hospital Infection Society. Published by Elsevier Ltd. Alt rights reserved.

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页码：105 / 109

页数：5

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