Physiology and pharmacology of iodized oil in goiter prophylaxis

被引:29
作者
Wolff, J [1 ]
机构
[1] NIDDKD, Lab Biochem & Genet, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1097/00005792-200101000-00003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid complications resulting from excess iodide such as thyrotoxicosis, thyroiditis, sialadenitis, or hypothyroidism are much rarer after iodine supplementation with Lipiodol than with KL They do not militate against its widespread use in endemic goiter populations, especially in pregnant women. However, patients with multinodular goiter should not be treated or should be treated only under careful observation. When Lipiodol-induced thyrotoxicosis occurs it tends to be mild or even subclinical and self-limited. If treatment is required, potassium perchlorate with or without thionamides is recommended. Iodide goiter has not been seen after Lipiodol supplementation, nor has thyroiditis. Sialadenitis occurs rarely. Iodide derived from Lipiodol readily enters the fetus, possibly by active transport, and theoretically endangers the fetus because autoregulation of the fetal thyroid occurs late during gestation. Despite the difficulty in distinguishing iodide goiter from iodide deficiency goiter of the newborn, no cases of neonatal iodide goiter have been reported. Possible mechanisms of thyroid inhibition by excess iodide are briefly discussed. The use of locally produced iodized plant oils is recommended for financial reasons as well as for the benefits derived from local participation.
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页码:20 / 36
页数:17
相关论文
共 138 条
[21]   Hepatic intraarterial I-131 iodized oil for treatment of hepatocellular carcinoma in patients with impeded portal venous flow [J].
de Baere, T ;
Taourel, P ;
Tubiana, JM ;
Kuoch, V ;
Ducreux, M ;
Lumbroso, J ;
Roche, AJ .
RADIOLOGY, 1999, 212 (03) :665-668
[22]  
Delange F, 1996, B WORLD HEALTH ORGAN, V74, P101
[23]   THE DISORDERS INDUCED BY IODINE DEFICIENCY [J].
DELANGE, F .
THYROID, 1994, 4 (01) :107-128
[24]  
DEPREZCURELY JP, 1962, ANN RADIOL, V5, P577
[25]   IDENTIFICATION OF DELTA-IODOLACTONE IN IODIDE TREATED HUMAN GOITER AND ITS INHIBITORY EFFECT ON PROLIFERATION OF HUMAN THYROID-FOLLICLES [J].
DUGRILLON, A ;
UEDELHOVEN, WM ;
PISAREV, MA ;
BECHTNER, G ;
GARTNER, R .
HORMONE AND METABOLIC RESEARCH, 1994, 26 (10) :465-469
[26]   Iodolactones and iodoaldehydes - Mediators of iodine in thyroid autoregulation [J].
Dugrillon, A .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1996, 104 :41-45
[27]   The prevention and management of iodine-induced hyperthyroidism and its cardiac features [J].
Dunn, JT ;
Semigran, MJ ;
Delange, F .
THYROID, 1998, 8 (01) :101-106
[28]  
DUNN JT, 1987, PREVENTION CONTROL I, P127
[29]   Concise review of the glutathione S-transferases and their significance to toxicology [J].
Eaton, DL ;
Bammler, TK .
TOXICOLOGICAL SCIENCES, 1999, 49 (02) :156-164
[30]   THE EFFECTS OF DIFFERENT DOSES OF ORAL IODIZED OIL ON GOITER SIZE, URINARY IODINE, AND THYROID-RELATED HORMONES [J].
ELNAGAR, B ;
ELTOM, M ;
KARLSSON, FA ;
ERMANS, AM ;
GEBREMEDHIN, M ;
BOURDOUX, PP .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (03) :891-897