Muscle as a "Mediator" of Systemic Metabolism

被引：273

作者：

Baskin, Kedryn K. ^{[1
]}

Winders, Benjamin R. ^{[1
,2
]}

Olson, Eric N. ^{[1
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2015年 / 21卷 / 02期

关键词：

PROLIFERATOR-ACTIVATED RECEPTOR; SKELETAL-MUSCLE; PPAR-GAMMA; ENERGY-METABOLISM; NUCLEAR RECEPTORS; ERR-ALPHA; TRANSCRIPTIONAL CONTROL; OXIDATIVE-METABOLISM; CARDIAC DYSFUNCTION; INSULIN-RESISTANCE;

D O I：

10.1016/j.cmet.2014.12.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.

引用

页码：237 / 248

页数：12

共 130 条

[1]

PPARγ signaling and metabolism: the good, the bad and the future [J].

Ahmadian, Maryam ;

Suh, Jae Myoung ;

Hah, Nasun ;

Liddle, Christopher ;

Atkins, Annette R. ;

Downes, Michael ;

Evans, Ronald M. .

NATURE MEDICINE, 2013, 19 (05) :557-566

[2]

ERRγ directs and maintains the transition to oxidative metabolism in the postnatal heart [J].

Alaynick, William A. ;

Kondo, Richard P. ;

Xie, Wen ;

He, Weimin ;

Dufour, Catherine R. ;

Downes, Michael ;

Jonker, Johan W. ;

Giles, Wayne ;

Naviaux, Robert K. ;

Giguere, Vincent ;

Evans, Ronald M. .

CELL METABOLISM, 2007, 6 (01) :13-24

[3]

Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance [J].

Amin, Rajesh H. ;

Mathews, Suresh T. ;

Camp, Heidi S. ;

Ding, Liyun ;

Leff, Todd .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2010, 298 (01) :E28-E37

[4]

[Anonymous], 2010, DRUG DISCOV TODAY DI, DOI DOI 10.1016/J.DDMEC.2010.08.001

[5]

Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle [J].

Arany, Z ;

He, HM ;

Lin, JD ;

Hoyer, K ;

Handschin, C ;

Toka, O ;

Ahmad, F ;

Matsui, T ;

Chin, S ;

Wu, PH ;

Rybkin, II ;

Shelton, JM ;

Manieri, M ;

Cinti, S ;

Schoen, FJ ;

Bassel-Duby, R ;

Rosenzweig, A ;

Ingwall, JS ;

Spiegelman, BM .

CELL METABOLISM, 2005, 1 (04) :259-271

[6]

Complexity in Transcription Control at the Activation Domain-Mediator Interface [J].

Balamotis, Michael A. ;

Pennella, Mario A. ;

Stevens, Jennitte L. ;

Wasylyk, Bohdan ;

Belmont, Andrew S. ;

Berk, Arnold J. .

SCIENCE SIGNALING, 2009, 2 (69) :ra20

[7]

MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver [J].

Baskin, Kedryn K. ;

Grueter, Chad E. ;

Kusminski, Christine M. ;

Holland, William L. ;

Bookout, Angie L. ;

Satapati, Santosh ;

Kong, Y. Megan ;

Burgess, Shawn C. ;

Malloy, Craig R. ;

Scherer, Philipp E. ;

Newgard, Christopher B. ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

EMBO MOLECULAR MEDICINE, 2014, 6 (12) :1610-1621

[8]

The heart-liver metabolic axis: defective communication exacerbates disease [J].

Baskin, Kedryn K. ;

Bookout, Angie L. ;

Olson, Eric N. .

EMBO MOLECULAR MEDICINE, 2014, 6 (04) :436-438

[9]

Signaling pathways in skeletal muscle remodeling [J].

Bassel-Duby, Rhonda ;

Olson, Eric N. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :19-37

[10]

MED1 phosphorylation promotes its association with Mediator: Implications for nuclear receptor signaling [J].

Belakavadi, Madesh ;

Pandey, Pradeep K. ;

Vijayvargia, Ravi ;

Fondell, Joseph D. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (12) :3932-3942

← 1 2 3 4 5 6 7 8 9 10 →