Nanoparticles as nonviral gene delivery vectors

被引：65

作者：

Ragusa, Andrea ^{[1
,4
]}

Garcia, Isabel ^{[1
,2
]}

Penades, Soledad ^{[1
,2
,3
]}

机构：

[1] CSIC, IIQ, Lab Glyconantechnol, Seville 41092, Spain

[2] CICbiomaGUNE, San Sebastian 20009, Spain

[3] CIBER BBN Networking Ctr Bioengn Biomat & Nanomed, San Sebastian 20009, Spain

[4] Distretto Tecnol ISUFI, INFM, CNR, Natl Nanotechnol Lab, I-73100 Lecce, Italy

来源：

IEEE TRANSACTIONS ON NANOBIOSCIENCE | 2007年 / 6卷 / 04期

关键词：

gene delivery; gene therapy; nanoparticles; nonviral vectors; transfection;

D O I：

10.1109/TNB.2007.908996

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Gene therapy, as therapeutic treatment to genetic or acquired diseases, is attracting much interest in the research community, leading to noteworthy developments over the past two decades. Although this field is still dominated by viral vectors, nonviral vectors have recently received an ever increasing attention in order to overcome the safety problems of their viral counterpart. This review presents the biological aspects involved in the gene delivery process and explores the recent developments and achievements of nonviral gene carriers.

引用

页码：319 / 330

页数：12

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