Reduced evolutionary rate in reemerged Ebola virus transmission chains

被引：60

作者：

Blackley, David J. ^{[1
]}

Wiley, Michael R. ^{[2
]}

Ladner, Jason T. ^{[2
]}

Fallah, Mosoka ^{[3
]}

Lo, Terrence ^{[1
]}

Gilbert, Merle L. ^{[2
]}

Gregory, Christopher ^{[1
]}

D'ambrozio, Jonathan ^{[2
]}

Coulter, Stewart ^{[1
]}

Mate, Suzanne ^{[2
]}

Balogun, Zephaniah ^{[1
]}

Kugelman, Jeffrey ^{[2
]}

Nwachukwu, William ^{[1
]}

Prieto, Karla ^{[2
]}

Yeiah, Adolphus ^{[3
]}

Amegashie, Fred ^{[3
]}

Kearney, Brian ^{[2
]}

Wisniewski, Meagan ^{[2
]}

Saindon, John ^{[1
]}

Schroth, Gary ^{[4
]}

Fakoli, Lawrence ^{[5
]}

Diclaro, Joseph W., II ^{[6
]}

Kuhn, Jens H. ^{[7
]}

Hensley, Lisa E. ^{[7
]}

Jahrling, Peter B. ^{[7
]}

Stroher, Ute ^{[1
]}

Nichol, Stuart T. ^{[7
]}

Massaquoi, Moses ^{[3
]}

Kateh, Francis ^{[3
]}

Clement, Peter ^{[8
]}

Gasasira, Alex ^{[8
]}

Bolay, Fatorma ^{[5
]}

Monroe, Stephan S. ^{[1
]}

Rambaut, Andrew ^{[9
,10
,11
]}

Sanchez-Lockhart, Mariano ^{[2
]}

Laney, A. Scott ^{[1
]}

Nyenswah, Tolbert ^{[3
]}

Christie, Athalia ^{[1
]}

Palacios, Gustavo ^{[2
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA

[2] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA

[3] Minist Hlth, Monrovia, Liberia

[4] Illumina Inc, San Diego, CA 92122 USA

[5] Liberian Inst Biomed Res, Charlesville, Liberia

[6] US Navy, Naval Med Res Unit 3, Cairo, Egypt

[7] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA

[8] WHO, CH-1211 Geneva 27, Switzerland

[9] Univ Edinburgh, Inst Evolutionary Biol, Edinburgh EH9 3FL, Midlothian, Scotland

[10] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA

[11] Univ Edinburgh, Ctr Immunol Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland

来源：

SCIENCE ADVANCES | 2016年 / 2卷 / 04期

关键词：

LIBERIA; SPREAD;

D O I：

10.1126/sciadv.1600378

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

On 29 June 2015, Liberia's respite from Ebola virus disease (EVD) was interrupted for the second time by a renewed outbreak ("flare-up") of seven confirmed cases. We demonstrate that, similar to the March 2015 flare-up associated with sexual transmission, this new flare-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission. Although distinct, Ebola virus (EBOV) genomes from both flare-ups exhibit significantly low genetic divergence, indicating a reduced rate of EBOV evolution during persistent infection. Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.

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