Emergence of Zaire Ebola Virus Disease in Guinea

被引：896

作者：

Baize, Sylvain ^{[1
,2
,3
]}

Pannetier, Delphine ^{[1
,4
]}

Oestereich, Lisa ^{[7
,8
]}

Rieger, Toni ^{[7
,8
]}

Koivogui, Lamine ^{[9
]}

Magassouba, N'Faly ^{[10
]}

Soropogui, Barre ^{[10
]}

Sow, Mamadou Saliou ^{[11
]}

Keita, Sakoba ^{[12
]}

De Clerck, Hilde ^{[17
]}

Tiffany, Amanda ^{[5
,18
]}

Dominguez, Gemma ^{[18
]}

Loua, Mathieu ^{[14
]}

Traore, Alexis ^{[15
]}

Kolie, Moussa ^{[16
]}

Malano, Emmanuel Roland ^{[13
]}

Heleze, Emmanuel ^{[13
]}

Bocquin, Anne ^{[1
,4
]}

Mely, Stephane ^{[1
,4
]}

Raoul, Herve ^{[4
]}

Caro, Valerie ^{[6
]}

Cadar, Daniel ^{[7
,8
]}

Gabriel, Martin ^{[7
,8
]}

Pahlmann, Meike ^{[8
]}

Tappe, Dennis ^{[7
,8
]}

Schmidt-Chanasit, Jonas ^{[7
,8
]}

Impouma, Benido ^{[20
]}

Diallo, Abdoul Karim ^{[13
]}

Formenty, Pierre ^{[19
]}

Van Herp, Michel ^{[17
]}

Guenther, Stephan ^{[7
,8
]}

机构：

[1] Univ Lyon 1, Natl Reference Ctr Viral Hemorrhag Fevers, F-69365 Lyon, France

[2] Univ Lyon 1, Inst Pasteur, Unite Biol Infect Virales Emergentes, F-69365 Lyon, France

[3] Univ Lyon 1, CIRI, Ecole Normale Super Lyon, INSERM,U1111, F-69365 Lyon, France

[4] INSERM Jean Merieux, Lab P4, Lyon, France

[5] Epictr, Paris, France

[6] Inst Pasteur, Unite Rech & Expertise Environm & Risques Infect, Paris, France

[7] World Hlth Org WHO, Bernhard Nocht Inst Trop Med, Collaborating Ctr Arbovirus & Hemorrhag Fever Ref, Hamburg, Germany

[8] German Ctr Infect Res DZIF, Hamburg, Germany

[9] Inst Natl Sante Publ, Conakry, Guinea

[10] Univ Gamal Abdel Nasser Conakry, Lab Fievres Hemorrag Guinee, Conakry, Guinea

[11] Hop Natl Donka, Serv Malad Infect & Trop, Conakry, Guinea

[12] Minist Hlth Guinea, Conakry, Guinea

[13] WHO, Conakry, Guinea

[14] Direct Reg Sante Nzerekore, Sect Prevent & Lutte Malad, Nzerekore, Guinea

[15] Direct Prefectorale Sante Gueckedou, Sect Prevent & Lutte Malad, Gueckedou, Guinea

[16] Hop Prefectoral Gueckedou, Gueckedou, Guinea

[17] Med Frontieres, Brussels, Belgium

[18] Med Frontieres, Geneva, Switzerland

[19] WHO, Geneva, Switzerland

[20] African Reg Off, Brazzaville, DEM REP CONGO

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2014年 / 371卷 / 15期

关键词：

LASSA-VIRUS; FILOVIRUSES; INFECTION; ASSAY;

D O I：

10.1056/NEJMoa1404505

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.

引用

页码：1418 / 1425

页数：8

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