Regulation of cephalosporin biosynthesis

被引：55

作者：

Schmitt, EK

Hoff, B

Kück, U

机构：

[1] Ruhr Univ Bochum, Lehrstuhl Allgemeine & Mol Bot, D-44780 Bochum, Germany

[2] Novartis Pharma AG, NPU, CH-4002 Basel, Switzerland

来源：

MOLECULAR BIOTECHNOLOGY OF FUNGAL BETA-LACTAM ANTIBIOTICS AND RELATED PEPTIDE SYNTHETASES | 2004年 / 88卷

关键词：

Acremonium chrysogenum; cephalosporin; gene regulation; transcription factors; genetic engineering;

D O I：

10.1007/b99256

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The filamentous fungus Acremonium chrsogenum is the natural producer of the beta-lactam antibiotic cephalosporin C and is as such used worldwide in major biotechnical applications. Albeit its profound industrial importance, there is still a limited understanding about the molecular mechanisms regulating cephalosporin biosynthesis in this fungus. This review focuses on various regulatory levels of cephalosporin biosynthesis. In addition to precursor and antibiotic biosynthesis, molecular genetic characteristics of cephalosporin biosynthesis genes and the knowledge of multiple layers of their regulatory expressional control, as well as the function of activators or repressors on cephalosporin biosynthesis are jointly being surveyed. Furthermore, this review summarizes (i) molecular features, which distinguish strains with different production levels and (ii) examples of molecular engineering approaches to A. chrysogenum.

引用

页码：1 / 43

页数：43

共 191 条

[81] CELL-FREE CONVERSION OF DELTA-(L-ALPHA-AMINOADIPYL)-L-CYSTEINYL-D-VALINE INTO AN ANTIBIOTIC WITH THE PROPERTIES OF ISOPENICILLIN-N IN CEPHALOSPORIUM-ACREMONIUM [J].