First total synthesis and determination of the absolute configuration of mueggelone

被引：31

作者：

Motoyoshi, H ^{[1
]}

Ishigami, K ^{[1
]}

Kitahara, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Sci, Bunkyo Ku, Tokyo 1138657, Japan

来源：

TETRAHEDRON | 2001年 / 57卷 / 18期

关键词：

asymmetric synthesis; reduction; lactonization; epoxides;

D O I：

10.1016/S0040-4020(01)00279-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

All the four possible stereoisomers of mueggelone, an inhibitor of fish development, were efficiently synthesized in a stereoselective manner starting from D-arabinose, and the absolute configuration was determined to be 9R, 12S, 13S. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3899 / 3908

页数：10

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