Chromosomal imbalances in sporadic neuroendocrine tumours of the thymus

被引：16

作者：

Rieker, RJ

Aulmann, S

Penzel, R

Schnabel, PA

Blaeker, H

Esposito, I

Morresi-Hauf, A

Otto, HF

Hecker, E

Dienemann, H

Schirmacher, P

Mechtersheimer, G

机构：

[1] Heidelberg Univ, Dept Pathol, D-69120 Heidelberg, Germany

[2] Asklepios Fachkliniken, Dept Pathol, D-82131 Gauting, Germany

[3] Klinikum Bremen Ost GGMBH, Dept Thorac Surg, D-28325 Bremen, Germany

[4] Univ Klinikum Heidelberg, Thoraxklin, Dept Thorac Surg, D-69126 Heidelberg, Germany

来源：

CANCER LETTERS | 2005年 / 223卷 / 01期

关键词：

neuroendocrine tumour; thymic carcinoid; thymus; CGH;

D O I：

10.1016/j.canlet.2004.10.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroendocrine (carcinoid) tumours of the thymus are rare neoplasms characterized by a highly malignant clinical behavior. Some of these tumors are associated with MEN1. In this study we evaluated 10 cases of sporadic thymic neuroendocrine tumours using immunohistochemistry and comparative genomic hybridization (CGH). All tumours showed a diffuse expression of neuron specific enolase (NSE) and synaptophysin. Chromosomal imbalances were detected in 8/10 cases, the most frequent gains were seen on chromosome Xp (3/10 cases), 7p, 7q, 11q, 12q, and 20q (2/10 each), losses were most frequently detected at 6q (5/10 each), 6p (3/10 each), 4q (3/10 each), 3p, 10q, 11q and 13q (2/10 each). These CGH data show a degree of overlap with chromosomal imbalances commonly observed in advanced thymomas. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

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页码：169 / 174

页数：6

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