Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder

被引:220
作者
Hall, D
Dhilla, A
Charalambous, A
Gogos, JA
Karayiorgou, M
机构
[1] Rockefeller Univ, Human Neurogenet Lab, New York, NY 10021 USA
[2] Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY USA
[3] Columbia Univ, Ctr Neurobiol & Behav, New York, NY USA
关键词
D O I
10.1086/377003
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We evaluated a possible association between the brain-derived neurotrophic factor ( BDNF) gene and susceptibility to obsessive-compulsive disorder (OCD) by genotyping a number of single-nucleotide polymorphisms ( SNPs) and one microsatellite marker from the extended BDNF locus in 164 triads with OCD. Extensive background linkage disequilibrium was observed at this locus. Single-locus transmission-distortion tests revealed significant evidence of association with the disease for all the BDNF gene markers tested, including a Val66Met variation affecting the sequence of the proBDNF protein. Analysis of multi-SNP haplotypes provided similar results. Haplotype transmission comparisons in this and previous studies point to a functionally distinct BDNF haplotype uniquely marked by the rare Met66 allele, which is undertransmitted and likely confers a protective effect in OCD and other psychiatric disorders.
引用
收藏
页码:370 / 376
页数:7
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