We evaluated a possible association between the brain-derived neurotrophic factor ( BDNF) gene and susceptibility to obsessive-compulsive disorder (OCD) by genotyping a number of single-nucleotide polymorphisms ( SNPs) and one microsatellite marker from the extended BDNF locus in 164 triads with OCD. Extensive background linkage disequilibrium was observed at this locus. Single-locus transmission-distortion tests revealed significant evidence of association with the disease for all the BDNF gene markers tested, including a Val66Met variation affecting the sequence of the proBDNF protein. Analysis of multi-SNP haplotypes provided similar results. Haplotype transmission comparisons in this and previous studies point to a functionally distinct BDNF haplotype uniquely marked by the rare Met66 allele, which is undertransmitted and likely confers a protective effect in OCD and other psychiatric disorders.
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Lyons, WE
;
Mamounas, LA
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USANCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Mamounas, LA
;
Ricaurte, GA
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Ricaurte, GA
;
Coppola, V
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Coppola, V
;
Reid, SW
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Reid, SW
;
Bora, SH
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Bora, SH
;
Wihler, C
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Wihler, C
;
Koliatsos, VE
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Koliatsos, VE
;
Tessarollo, L
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Lyons, WE
;
Mamounas, LA
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USANCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Mamounas, LA
;
Ricaurte, GA
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Ricaurte, GA
;
Coppola, V
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Coppola, V
;
Reid, SW
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Reid, SW
;
Bora, SH
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Bora, SH
;
Wihler, C
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Wihler, C
;
Koliatsos, VE
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
Koliatsos, VE
;
Tessarollo, L
论文数: 0引用数: 0
h-index: 0
机构:NCI, Neurol Dev Grp, Adv Biosci Labs, Basic Res Program,Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA