Mild regioselective monobromination of activated aromatics and hetero-aromatics with N-bromosuccinimide in tetrabutylammonium bromide

被引：70

作者：

Ganguly, NC ^{[1
]}

De, P ^{[1
]}

Dutta, S ^{[1
]}

机构：

[1] Kalyani Univ, Dept Chem, Kalyani 741235, W Bengal, India

来源：

SYNTHESIS-STUTTGART | 2005年 / 07期

关键词：

bromination; ionic liquid; tetrabutylammonium bromide; N-bromosuccinimide; aromatics; heteroaromatics; regioselectivity;

D O I：

10.1055/s-2005-861866

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regioselective nuclear bromination of activated aromatic and heteroaromatic compounds has been accomplished using N-bromosuccinimide in tetrabutyl ammonium bromide. Predominant para-selective monobromination of activated aromatics such as phenols and anilines, rate acceleration of bromination for moderately activated and less reactive substrates on addition of acidic montmorillonite K-10 clay, with or without microwave assistance, are the notable features of this protocol.

引用

页码：1103 / 1108

页数：6

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