Novel use of a genetic algorithm for protein structure prediction: Searching template and sequence alignment space

被引：17

作者：

Contreras-Moreira, B ^{[1
]}

Fitzjohn, PW ^{[1
]}

Offman, M ^{[1
]}

Smith, GR ^{[1
]}

Bates, PA ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Lincolns Inn Fields, Biomol Modelling Lab, London WC2A 3PX, England

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2003年 / 53卷

关键词：

fold recognition; comparative modeling; genetic algorithms; template selection; alignment errors;

D O I：

10.1002/prot.10549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel genetic algorithm was applied to all CASP5 targets. The algorithm simultaneously searches template and alignment space. Results show that the current implementation of the method is perhaps most useful in recognizing and refining remote homology targets. This new method is briefly described and results are analyzed. Strengths and weaknesses of the current implementation of the algorithm are discussed. (C) 2003 Wiley-Liss, Inc.

引用

页码：424 / 429

页数：6

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