DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses

被引:67
作者
Harris, RS
Sheehy, AM
Craig, HM
Malim, MH
Neuberger, MS
机构
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] Kings Coll London, Guys Kings & St Thomas Sch Med, Dept Infect Dis, London SE1 9RT, England
关键词
D O I
10.1038/ni0703-641
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
New insights into APOBEC editing functions suggest this family of enzymes might protect against invasive attack by foreign DNA.
引用
收藏
页码:641 / 643
页数:3
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共 29 条
  • [1] C-to-U RNA editing: Mechanisms leading to genetic diversity
    Blanc, V
    Davidson, NO
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) : 1395 - 1398
  • [2] A HIGHLY DEFECTIVE HIV-1 GROUP-O PROVIRUS - EVIDENCE FOR THE ROLE OF LOCAL SEQUENCE DETERMINANTS IN G-]A HYPERMUTATION DURING NEGATIVE-STRAND VIRAL-DNA SYNTHESIS
    BORMAN, AM
    QUILLENT, C
    CHARNEAU, P
    KEAN, KM
    CLAVEL, F
    [J]. VIROLOGY, 1995, 208 (02) : 601 - 609
  • [3] Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    Bransteitter, R
    Pham, P
    Scharff, MD
    Goodman, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 4102 - 4107
  • [4] Transcription-targeted DNA deamination by the AID antibody diversification enzyme
    Chaudhuri, J
    Tian, M
    Khuong, C
    Chua, K
    Pinaud, E
    Alt, FW
    [J]. NATURE, 2003, 422 (6933) : 726 - 730
  • [5] AID mediates hypermutation by deaminating single stranded DNA
    Dickerson, SK
    Market, E
    Besmer, E
    Papavasiliou, EN
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (10) : 1291 - 1296
  • [6] A NEW-TYPE OF G-]A HYPERMUTATION AFFECTING HUMAN-IMMUNODEFICIENCY-VIRUS
    FITZGIBBON, JE
    MAZAR, S
    DUBIN, DT
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1993, 9 (09) : 833 - 838
  • [7] ROLE OF VIF IN REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN CD4+ T LYMPHOCYTES
    GABUZDA, DH
    LAWRENCE, K
    LANGHOFF, E
    TERWILLIGER, E
    DORFMAN, T
    HASELTINE, WA
    SODROSKI, J
    [J]. JOURNAL OF VIROLOGY, 1992, 66 (11) : 6489 - 6495
  • [8] Naturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G->A hypermutation
    Gunther, S
    Sommer, G
    Plikat, U
    Iwanska, A
    WainHobson, S
    Will, H
    Meyerhans, A
    [J]. VIROLOGY, 1997, 235 (01) : 104 - 108
  • [9] DNA determination mediates innate immunity to retroviral infection
    Harris, RS
    Bishop, KN
    Sheehy, AM
    Craig, HM
    Petersen-Mahrt, SK
    Watt, IN
    Neuberger, MS
    Malim, MH
    [J]. CELL, 2003, 113 (06) : 803 - 809
  • [10] RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators
    Harris, RS
    Petersen-Mahrt, SK
    Neuberger, MS
    [J]. MOLECULAR CELL, 2002, 10 (05) : 1247 - 1253