The vasculopathy of Raynaud's phenomenon and scleroderma

被引：65

作者：

Flavahan, NA ^{[1
]}

Flavahan, S ^{[1
]}

Mitra, S ^{[1
]}

Chotani, MA ^{[1
]}

机构：

[1] Ohio State Univ, Heart & Lung Res Inst, Columbus, OH 43210 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2003年 / 29卷 / 02期

关键词：

D O I：

10.1016/S0889-857X(03)00021-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The scleroderma (SSc) disease process involves dramatic dysfunction in acute and chronic vascular regulatory mechanisms; it presents initially with heightened vasoconstrictor or vasospastic activity and progresses to structural derangement or vasculopathy of the microcirculation. This article discusses the regulatory mechanisms that contribute to this dysfunction and the vascular changes in the context of the other aspects of the SSc disease process in a novel attempt to integrate the individual pathologies of the disease process.

引用

页码：275 / +

页数：18

共 135 条

[21] Subtype-specific intracellular trafficking of alpha(2)-adrenergic receptors [J].

Daunt, DA ;

Hurt, C ;

Hein, L ;

Kallio, J ;

Feng, F ;

Kobilka, BK .

MOLECULAR PHARMACOLOGY, 1997, 51 (05) :711-720

[22]

DAVIS EC, 1994, J CELL SCI, V107, P727

[23] Mouse models of genetic diseases resulting from mutations in elastic fiber proteins [J].

Dietz, HC ;

Mecham, RP .

MATRIX BIOLOGY, 2000, 19 (06) :481-488

[24]

Dingemans KP, 2000, ANAT REC, V258, P1

[25] Angiogenic and angiostatic factors in systemic sclerosis:: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers -: art. no. R11 [J].

Distler, O ;

del Rosso, A ;

Giacomelli, R ;

Cipriani, P ;

Conforti, ML ;

Guiducci, S ;

Gay, RE ;

Michel, BA ;

Brühlmann, P ;

Ladner, UM ;

Gay, S ;

Matucci-Cerinic, M .

ARTHRITIS RESEARCH, 2002, 4 (06) :R11

[26] RETRACTED: Deficient Smad7 expression: A putative molecular defect in scleroderma (Retracted Article) [J].

Dong, CM ;

Zhu, SK ;

Wang, T ;

Yoon, W ;

Li, ZR ;

Alvarez, RJ ;

ten Dijke, P ;

White, B ;

Wigley, FM ;

Goldschmidt-Clermont, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3908-3913

[27] ALPHA-2-ADRENERGIC RECEPTOR LEVELS IN OBSTRUCTIVE AND SPASTIC RAYNAUDS SYNDROME [J].

EDWARDS, JM ;

PHINNEY, ES ;

TAYLOR, LM ;

KEENAN, EJ ;

PORTER, JM .

JOURNAL OF VASCULAR SURGERY, 1987, 5 (01) :38-45

[28] ALPHA-ADRENOCEPTORS AND COLD-INDUCED VASOCONSTRICTION IN HUMAN FINGER SKIN [J].

EKENVALL, L ;

LINDBLAD, LE ;

NORBECK, O ;

ETZELL, BM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (05) :H1000-H1003

[29] EFFECT OF LOCAL TISSUE COOLING ON MICROVASCULAR SMOOTH-MUSCLE AND POSTJUNCTIONAL ALPHA-2-ADRENOCEPTORS [J].

FABER, JE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (01) :H120-H130

[30] High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis [J].

Fatini, C ;

Gensini, F ;

Sticchi, E ;

Battaglini, B ;

Angotti, C ;

Conforti, ML ;

Generini, S ;

Pignone, A ;

Abbate, R ;

Matucci-Cerinic, M .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (07) :540-544

← 1 2 3 4 5 6 7 8 9 10 →