A general synthesis of beta-aryl and heteroarylpyrroles by palladium-catalyzed coupling reaction of beta-tributylstannylpyrrole with aryl and heteroaryl halides

被引:20
作者
Wang, JJ [1 ]
Scott, AI [1 ]
机构
[1] TEXAS A&M UNIV,DEPT CHEM,CTR BIOL NMR,COLLEGE STN,TX 77843
关键词
D O I
10.1016/0040-4039(96)00530-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Several beta-aryl and heteroarylpyrroles have been synthesized by palladium-catalyzed coupling reaction of beta-tributylstannylpyrroles with aryl and heteroaryl halides in 62-89% yields. These precursors may be readily converted into beta-aryl and heteroaryl substituted porphyrins for the study of the oxophlorin to oxaporphyrin conversion in heme catabolism, catalyzed by heme oxygenase. (C) 1996 Elsevier Science Ltd.
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页码:3247 / 3250
页数:4
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