A general synthesis of beta-aryl and heteroarylpyrroles by palladium-catalyzed coupling reaction of beta-tributylstannylpyrrole with aryl and heteroaryl halides
Several beta-aryl and heteroarylpyrroles have been synthesized by palladium-catalyzed coupling reaction of beta-tributylstannylpyrroles with aryl and heteroaryl halides in 62-89% yields. These precursors may be readily converted into beta-aryl and heteroaryl substituted porphyrins for the study of the oxophlorin to oxaporphyrin conversion in heme catabolism, catalyzed by heme oxygenase. (C) 1996 Elsevier Science Ltd.