A potential panel of six-long non-coding RNA signature to improve survival prediction of diffuse large-B-cell lymphoma

被引:71
作者
Sun, Jie [1 ]
Cheng, Liang [1 ]
Shi, Hongbo [1 ]
Zhang, Zhaoyue [1 ]
Zhao, Hengqiang [1 ]
Wang, Zhenzhen [1 ]
Zhou, Meng [1 ]
机构
[1] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150081, Peoples R China
来源
SCIENTIFIC REPORTS | 2016年 / 6卷
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
EXPRESSION; PROGNOSIS; IDENTIFICATION; EXPLORATION;
D O I
10.1038/srep27842
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology and have been implicated in the development and progression of cancers. However, the prognostic significance of lncRNAs in diffuse large-B-cell lymphoma (DLBCL) remains unclear and needs to be systematically investigated. In this study, we obtained and analyzed lncRNA expression profiles in three cohorts of 1043 DLBCL patients by repurposing the publicly available microarray datasets from the Gene Expression Omnibus (GEO) database. In the discovery series of 207 patients, we identified a set of six lncRNAs that was significantly associated with patients' overall survival (OS) using univariate Cox regression analysis. The six prognostic lncRNAs were combined to form an expression-based six-lncRNA signature which classified patients of the discovery series into the high-risk group and low-risk group with significantly different survival outcome (HR = 2.31, 95% CI = 1.8 to 2.965, p < 0.001). The six-lncRNA signature was further confirmed in the internal testing series and two additional independent datasets with different array platform. Moreover, the prognostic value of the six-lncRNA signature is independent of conventional clinical factors. Functional analysis suggested that six-lncRNA signature may be involved with DLBCL through exerting their regulatory roles in known cancer-related pathways, immune system and signaling molecules interaction.
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页数:10
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共 39 条
  • [1] Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment
    Alizadeh, Ash A.
    Gentles, Andrew J.
    Alencar, Alvaro J.
    Liu, Chih Long
    Kohrt, Holbrook E.
    Houot, Roch
    Goldstein, Matthew J.
    Zhao, Shuchun
    Natkunam, Yasodha
    Advani, Ranjana H.
    Gascoyne, Randy D.
    Briones, Javier
    Tibshirani, Robert J.
    Myklebust, June H.
    Plevritis, Sylvia K.
    Lossos, Izidore S.
    Levy, Ronald
    [J]. BLOOD, 2011, 118 (05) : 1350 - 1358
  • [2] [Anonymous], ONCOTARGET
  • [3] Bret C, 2012, ONCOTARGET, V3, P1700
  • [4] Long noncoding RNAs and the genetics of cancer
    Cheetham, S. W.
    Gruhl, F.
    Mattick, J. S.
    Dinger, M. E.
    [J]. BRITISH JOURNAL OF CANCER, 2013, 108 (12) : 2419 - 2425
  • [5] Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer
    Crea, Francesco
    Watahiki, Akira
    Quagliata, Luca
    Xue, Hui
    Pikor, Larissa
    Parolia, Abhijit
    Wang, Yuwei
    Lin, Dong
    Lam, Wan L.
    Farrar, William L.
    Isogai, Takao
    Morant, Rudolf
    Castori-Eppenberger, Serenella
    Chi, Kim N.
    Wang, Yuzhuo
    Helgason, Cheryl D.
    [J]. ONCOTARGET, 2014, 5 (03) : 764 - 774
  • [6] The functional role of long non-coding RNA in human carcinomas
    Gibb, Ewan A.
    Brown, Carolyn J.
    Lam, Wan L.
    [J]. MOLECULAR CANCER, 2011, 10
  • [7] Gene Coexpression Networks in Human Brain Developmental Transcriptomes Implicate the Association of Long Noncoding RNAs with Intellectual Disability
    Gudenas, Brian L.
    Wang, Liangjiang
    [J]. BIOINFORMATICS AND BIOLOGY INSIGHTS, 2015, 9 : 21 - 27
  • [8] Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs
    Hangauer, Matthew J.
    Vaughn, Ian W.
    McManus, Michael T.
    [J]. PLOS GENETICS, 2013, 9 (06):
  • [9] Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma
    Hao, Yibin
    Wu, Wei
    Shi, Fachun
    Dalmolin, Rodrigo J. S.
    Yan, Ming
    Tian, Fu
    Chen, Xiaobing
    Chen, Guoyong
    Cao, Wei
    [J]. BMC CANCER, 2015, 15
  • [10] Long Non-Coding RNA in Cancer
    Hauptman, Nina
    Glavac, Damjan
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (03) : 4655 - 4669