A study on the differentiation between amorphous piroxicam:beta-cyclodextrin complex and a mixture of the two amorphous components

被引：41

作者：

Redenti, E

Peveri, T

Zanol, M

Ventura, P

Gnappi, G

Montenero, A

机构：

[1] CORIVE,I-43100 PARMA,ITALY

[2] UNIV PARMA,DIPARTIMENTO CHIM GEN & INORGAN,I-43100 PARMA,ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 129卷 / 1-2期

关键词：

piroxicam; beta-cyclodextrin; inclusion complexes; differential scanning calorimetry; NIR FT Raman; X-ray diffractometry; glassy state; melt spinning;

D O I：

10.1016/0378-5173(95)04357-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amorphous piroxicam was prepared by the melt spinning method to prove that freeze-dried amorphous piroxicam:beta-cyclodextrin is a true inclusion compound and not a dispersed mixture of the two amorphous components. Differential scanning calorimetry (DSC) and near-infrared Fourier transform Raman spectroscopy (NIR FT-Raman) established the success of the encapsulation. Thermal analysis can also be used to evaluate the inclusion complex purity with regard to crystalline and/or amorphous free piroxicam content.

引用

页码：289 / 294

页数：6

共 19 条

[1]

ACERBI D, 1990, DRUG INVEST S4, V2, P29

[2]

[Anonymous], PHARM THERMAL ANAL

[3] IR AND EXAFS ANALYSIS OF XBI(2)O(3).(1-X)GEO2 GLASSES [J].