Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport

被引：346

作者：

Heisler, Marcus G. ^{[1
]}

Hamant, Olivier ^{[2
]}

Krupinski, Pawel ^{[3
]}

Uyttewaal, Magalie ^{[2
]}

Ohno, Carolyn ^{[1
]}

Jonsson, Henrik ^{[3
]}

Traas, Jan ^{[2
]}

Meyerowitz, Elliot M. ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

[2] Univ Lyon, ENS, CNRS, INRA, Lyon, France

[3] Lund Univ, Dept Theoret Phys, Computat Biol & Biol Phys Grp, S-22362 Lund, Sweden

来源：

PLOS BIOLOGY | 2010年 / 8卷 / 10期

基金：

瑞典研究理事会; 美国能源部;

关键词：

CORTICAL MICROTUBULES; ARABIDOPSIS-THALIANA; GENE-EXPRESSION; PLASMA-MEMBRANE; PHYLLOTAXIS; PROTEINS; GROWTH; PLANTS; INITIATION; INDUCTION;

D O I：

10.1371/journal.pbio.1000516

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells. In particular, normal patterns of organogenesis in plants require coordination between growth direction and growth magnitude. How this is achieved remains unclear. Here we show that in Arabidopsis thaliana, auxin patterning and cellular growth are linked through a correlated pattern of auxin efflux carrier localization and cortical microtubule orientation. Our experiments reveal that both PIN1 localization and microtubule array orientation are likely to respond to a shared upstream regulator that appears to be biomechanical in nature. Lastly, through mathematical modeling we show that such a biophysical coupling could mediate the feedback loop between auxin and its transport that underlies plant phyllotaxis.

引用

页数：12

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[31] Real-time lineage analysis reveals oriented cell divisions associated with morphogenesis at the shoot apex of Arabidopsis thaliana [J].