Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera

被引:22
作者
D'Andrea, C
Comelli, D
Pifferi, A
Torricelli, A
Valentini, G
Cubeddu, R [1 ]
机构
[1] INFM, Dipartimento Fis, I-20133 Milan, Italy
[2] Politecn Milan, IFN, CNR, I-20133 Milan, Italy
关键词
D O I
10.1088/0022-3727/36/14/304
中图分类号
O59 [应用物理学];
学科分类号
摘要
In this paper, we propose a novel approach for the acquisition of time-resolved data for optical tomography. A fast gated CCD has been used as a parallel detector to acquire in one shot the light intensity exiting a phantom within a very short time slice. By using a pulsed illumination and repeating the acquisition at different delays, the time behaviour of the diffused transmittance can be recorded very quickly. Scattering inclusions embedded in a 5 cm thick phantom have been revealed by fitting a set of 120 images, delayed 50 ps from one another, with a mathematical model based on the random walk theory. Moreover, absorption inclusions have been detected in time-gated images taken at suitable delays.
引用
收藏
页码:1675 / 1681
页数:7
相关论文
共 24 条
[1]   Optical imaging in medicine .2. Modelling and reconstruction [J].
Arridge, SR ;
Hebden, JC .
PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (05) :841-853
[2]   Optical tomography in medical imaging [J].
Arridge, SR .
INVERSE PROBLEMS, 1999, 15 (02) :R41-R93
[3]   MODEL FOR PHOTON MIGRATION IN TURBID BIOLOGICAL MEDIA [J].
BONNER, RF ;
NOSSAL, R ;
HAVLIN, S ;
WEISS, GH .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1987, 4 (03) :423-432
[4]   Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements [J].
Cai, W ;
Gayen, SK ;
Xu, M ;
Zevallos, M ;
Alrubaiee, M ;
Lax, M ;
Alfano, RR .
APPLIED OPTICS, 1999, 38 (19) :4237-4246
[5]   Effect of lateral boundaries on contrast functions in time-resolved transillumination measurements [J].
Chernomordik, V ;
Gandjbakhche, AH ;
Hebden, JC ;
Zaccanti, G .
MEDICAL PHYSICS, 1999, 26 (09) :1822-1831
[6]   Imaging with diffusing light: an experimental study of the effect of background optical properties [J].
Cubeddu, R ;
Pifferi, A ;
Taroni, P ;
Torricelli, A ;
Valentini, G .
APPLIED OPTICS, 1998, 37 (16) :3564-3573
[7]   Time-resolved imaging on a realistic tissue phantom: mu(s)' and mu(a) images versus time-integrated images [J].
Cubeddu, R ;
Pifferi, A ;
Taroni, P ;
Torricelli, A ;
Valentini, G .
APPLIED OPTICS, 1996, 35 (22) :4533-4540
[8]   Dual-wavelength time-resolved optical mammograph for clinical studies [J].
Cubeddu, R ;
Giambattistelli, E ;
Pifferi, A ;
Taroni, P ;
Torricelli, A .
PHOTON MIGRATION, OPTICAL COHERENCE TOMOGRAPHY, AND MICROSCOPY, 2001, 4431 :195-198
[9]   Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions [J].
Cubeddu, R ;
Pifferi, A ;
Taroni, P ;
Torricelli, A ;
Valentini, G .
APPLIED PHYSICS LETTERS, 1996, 69 (27) :4162-4164
[10]   Time-resolved fluorescence imaging in biology and medicine [J].
Cubeddu, R ;
Comelli, D ;
D'Andrea, C ;
Taroni, P ;
Valentini, G .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2002, 35 (09) :R61-R76