Cell-to-cell fusion as a link between viruses and cancer

被引:144
作者
Duelli, Dominik
Lazebnik, Yuri
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] Rosalind Franklin Univ Med Sci, Chicago Med Sch, Dept Pathol, N Chicago, IL 60064 USA
关键词
D O I
10.1038/nrc2272
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The ability to fuse cells is shared by many viruses, including common human pathogens and several endogenous viruses. Here we will discuss how cell fusion can link viruses to cancer, what types of cancers it can affect, how the existence of this link can be tested and how the hypotheses that we propose might affect the search for human oncogenic viruses. In particular, we will focus on the ability of cell fusion that is caused by viruses to induce chromosomal instability, a common affliction of cancer cells that has been thought to underlie the malignant properties of cancerous tumours.
引用
收藏
页码:968 / 976
页数:9
相关论文
共 135 条
  • [31] Recent trends in cancer mortality in the UK
    Doll, R
    Boreham, J
    [J]. BRITISH JOURNAL OF CANCER, 2005, 92 (07) : 1329 - 1335
  • [32] Cell fusion: A hidden enemy?
    Duelli, D
    Lazebnik, Y
    [J]. CANCER CELL, 2003, 3 (05) : 445 - 448
  • [33] A primate virus generates transformed human cells by fusion
    Duelli, DM
    Hearn, S
    Myers, MP
    Lazebnik, Y
    [J]. JOURNAL OF CELL BIOLOGY, 2005, 171 (03) : 493 - 503
  • [34] Primary cells suppress oncogene-dependent apoptosis
    Duelli, DM
    Lazebnik, YA
    [J]. NATURE CELL BIOLOGY, 2000, 2 (11) : 859 - 862
  • [35] A virus causes cancer by inducing massive chromosomal instability through cell fusion
    Duelli, Dominik M.
    Padilla-Nash, Hesed M.
    Berman, David
    Murphy, Kathleen M.
    Ried, Thomas
    Lazebnik, Yuri
    [J]. CURRENT BIOLOGY, 2007, 17 (05) : 431 - 437
  • [36] Centrosornes, genomic instability, and cervical carcinogenesis
    Duensing, S
    Münger, K
    [J]. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2003, 13 (01): : 9 - 23
  • [37] Duesberg P, 2005, CELL ONCOL, V27, P293
  • [38] DNA viruses in human cancer: An integrated overview on fundamental mechanisms of viral carcinogenesis
    Elgui de Oliveira, Deilson
    [J]. CANCER LETTERS, 2007, 247 (02) : 182 - 196
  • [39] Evans Alfred S., 1990, Annals of Epidemiology, V1, P71
  • [40] Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer
    Feng Wang-Johanning
    Liu, Jinsong
    Rycaj, Kiera
    Huang, Miao
    Tsai, Kate
    Rosen, Daniel G.
    Chen, Dung-Tsa
    Lu, Danielle W.
    Barnhart, Kirstin F.
    Johanning, Gary L.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (01) : 81 - 90