Production of antibodies in transgenic plants

被引：49

作者：

Larrick, JW

Yu, L

Chen, J

Jaiswal, S

Wycoff, K

机构：

[1] Palo Alto Inst Mol Med, Mt View, CA 94043 USA

[2] Planet Biotechnol Inc, Mt View, CA 94043 USA

来源：

RESEARCH IN IMMUNOLOGY | 1998年 / 149卷 / 06期

关键词：

D O I：

10.1016/S0923-2494(98)80013-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plants offer a cost-effective bioreactor to produce antibodies of diverse types. Recent studies demonstrate the secretory IgA, the predominant antibody isotype of the mucosal immune system, can be made in large quantities in plants. CaroRx(TM), the technology Inc., has demonstrated activity in pilot phase II trials versus S. mutans, the major pathogen contributing to development of dental caries. Numerous other SIgA plantibodies are in preclinical development.

引用

页码：603 / 608

页数：6

共 45 条

[41] TRANSGENIC PLANTS EXPRESSING A FUNCTIONAL SINGLE-CHAIN FV-ANTIBODY ARE SPECIFICALLY PROTECTED FROM VIRUS ATTACK [J].