Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression

被引：27

作者：

Hammond, Abdulrahman S. ^{[1
]}

McConkey, Samuel J. ^{[1
]}

Hill, Philip C. ^{[1
]}

Crozier, Sarah ^{[1
]}

Klein, Michel R. ^{[1
]}

Adegbola, Richard A. ^{[1
]}

Rowland-Jones, Sarah ^{[1
]}

Brookes, Roger H. ^{[1
]}

Whittle, Hilton ^{[1
]}

Jaye, Assan ^{[1
]}

机构：

[1] MRC Labs, Bacterial & Viral Dis Programme, Fajara, Gambia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1086/524685

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT) -6, and culture filtrate protein (CFP) -10 antigens for interferon (IFN)-gamma-producing effector T cell responses by direct ex vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-gamma secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis.

引用

页码：295 / 299

页数：5

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