The human orbitofrontal cortex: Linking reward to hedonic experience

被引:1543
作者
Kringelbach, ML
机构
[1] Univ Oxford, Univ Lab Physiol, Oxford OX1 3PT, England
[2] John Radcliffe Hosp, Oxford Ctr Funct Magnet Resonance Imaging Brain, FMRIB, Oxford OX3 9DU, England
基金
英国惠康基金;
关键词
D O I
10.1038/nrn1747
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hedonic experience is arguably at the heart of what makes us human. In recent neuroimaging studies of the cortical networks that mediate hedonic experience in the human brain, the orbitofrontal cortex has emerged as the strongest candidate for linking food and other types of reward to hedonic experience. The orbitofrontal cortex is among the least understood regions of the human brain, but has been proposed to be involved in sensory integration, in representing the affective value of reinforcers, and in decision making and expectation. Here, the functional neuroanatomy of the human orbitofrontal cortex is described and a new integrated model of its functions proposed, including a possible role in the mediation of hedonic experience.
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页码:691 / 702
页数:12
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