The development of gene therapy for diseases of the lung

被引：44

作者：

Gill, DR ^{[1
]}

Davies, LA ^{[1
]}

Pringle, IA ^{[1
]}

Hyde, SC ^{[1
]}

机构：

[1] UK Cyst Fibrosis Gene Therapy Consortium, Univ Oxford, John Radcliffe Hosp, NDCLS,Gene Med Res Grp, Oxford OX3 9DU, England

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 03期

关键词：

gene therapy; lung disease; cystic fibrosis; emphysema; adenovirus; adeno-associated virus; DNA/liposome; promoter attenuation;

D O I：

10.1007/s00018-003-3317-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of a successful gene therapy has many stages, including preclinical testing in animal models and proof of principle clinical studies. A variety of diseases affect the lung, which are candidates for gene therapy; this review will mainly focus on the diseases that have attracted the most attention and have therefore yielded the most progress, namely lung cancer and the monogenic disorder cystic fibrosis. Knowledge gained from clinical studies could eventually be applied to more complex lung conditions such as acute respiratory distress syndrome and asthma. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery.

引用

收藏

页码：355 / 368

页数：14

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