Regulation of macrophage functions by PPAR-α, PPAR-γ, and LXRs in mice and men

被引：247

作者：

Rigamonti, Elena

Chinetti-Gbaguidi, Giulia

Staels, Bart

机构：

[1] Inst Pasteur, INSERM, U545, F-59019 Lille, France

[2] Univ Lille 2, Fac Pharm & Med, Lille, France

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2008年 / 28卷 / 06期

关键词：

nuclear receptors; atherosclerosis; lipid metabolism; inflammation;

D O I：

10.1161/ATVBAHA.107.158998

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) and (liver X receptors) LXRs are ligand-activated transcription factors that control lipid and glucose metabolism, as well as the inflammatory response. Because the macrophage plays an important role in host defense and immunoinflammatory pathologies, particular attention has been paid to the role of PPARs and LXRs in the control of macrophage gene expression and function. Research over the last few years has revealed important roles for PPAR-alpha, PPAR-gamma, and LXRs in macrophage inflammation and cholesterol homeostasis with consequences for atherosclerosis development. In this review we will discuss the role of these transcription factors in the control of macrophage activities, with particular attention to species-differences in macrophage function control by PPARs and LXR between rodents and humans.

引用

页码：1050 / 1059

页数：10

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