Establishment of the vertebrate kinetochores

被引：27

作者：

Hori, Tetsuya ^{[1
,2
]}

Fukagawa, Tatsuo ^{[1
,2
]}

机构：

[1] Natl Inst Genet, Dept Mol Genet, Mishima, Shizuoka 4118540, Japan

[2] Grad Univ Adv Studies, Mishima, Shizuoka 4118540, Japan

来源：

CHROMOSOME RESEARCH | 2012年 / 20卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

Centromere; Kinetochore; CCAN; KMN; CENP-A NUCLEOSOMES; CONSTITUTIVE CENTROMERE COMPONENT; B NULL MICE; MICROTUBULE-BINDING; AURORA B; CHROMOSOME SEGREGATION; OUTER KINETOCHORE; MITOTIC CHECKPOINT; INNER CENTROMERE; MOLECULAR ARCHITECTURE;

D O I：

10.1007/s10577-012-9289-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The centromere is essential for accurate chromosome segregation during mitosis and meiosis to achieve transmission of genetic information to daughter cells. To facilitate accurate chromosome segregation, the centromere serves several specific functions, including microtubule binding, spindle-checkpoint control, and sister chromatid cohesion. The kinetochore is formed on the centromere to achieve these functions. To understand kinetochore structure and function, it is critical to identify the protein components of the kinetochore and characterize the functional properties of each component. Here, we review recent progress with regard to the molecular architecture of the kinetochore and discuss the future directions for centromere biology.

引用

页码：547 / 561

页数：15

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