Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes

被引：267

作者：

Black, Ben E. ^{[1
]}

Cleveland, Don W. ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

CELL | 2011年 / 144卷 / 04期

基金：

美国国家卫生研究院;

关键词：

E3 UBIQUITIN LIGASE; FISSION YEAST SCM3; HISTONE H3 VARIANT; CHROMATIN REQUIRES; MAINTENANCE; DOMAIN; CSE4; ORGANIZATION; REPLICATION; RECOGNITION;

D O I：

10.1016/j.cell.2011.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Centromeres direct chromosome inheritance, but in multicellular organisms their positions on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The major candidate for the epigenetic mark is chromatin assembled with the histone H3 variant CENP-A. Recent studies offer conflicting evidence for the structure of CENP-A-containing chromatin, including the histone composition and handedness of the DNA wrapped around the histones. We present a model for the assembly and deposition of centromeric nucleosomes that couples these processes to the cell cycle. This model reconciles divergent data for CENP-A-containing nucleosomes and provides a basis for how centromere identity is stably inherited.

引用

页码：471 / 479

页数：9

共 53 条

[1] Human centromere repositioning "in progress" [J].

Amor, DJ ;

Bentley, K ;

Ryan, J ;

Perry, J ;

Wong, L ;

Slater, H ;

Choo, KHA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6542-6547

[2] Nucleosome chiral transition under positive torsional stress in single chromatin fibers [J].

Bancaud, Aurelien ;

Wagner, Gaudeline ;

Conde e Silva, Natalia ;

Lavelle, Christophe ;

Wong, Hua ;

Mozziconacci, Julien ;

Barbi, Maria ;

Sivolob, Andrei ;

Le Cam, Eric ;

Mouawad, Liliane ;

Viovy, Jean-Louis ;

Victor, Jean-Marc ;

Prunell, Ariel .

MOLECULAR CELL, 2007, 27 (01) :135-147

[3] Structural determinants for generating centromeric chromatin [J].

Black, BE ;

Foltz, DR ;

Chakravarthy, S ;

Luger, K ;

Woods, VL ;

Cleveland, DW .

NATURE, 2004, 430 (6999) :578-582

[4] The histone variant CENP-A and centromere specification [J].

Black, Ben E. ;

Bassett, Emily A. .

CURRENT OPINION IN CELL BIOLOGY, 2008, 20 (01) :91-100

[5] An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes [J].

Black, Ben E. ;

Brock, Melissa A. ;

Bedard, Sabrina ;

Woods, Virgil L., Jr. ;

Cleveland, Don W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5008-5013

[6] Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain [J].

Black, Ben E. ;

Jansen, Lars E. T. ;

Maddox, Paul S. ;

Foltz, Daniel R. ;

Desai, Arshad B. ;

Shah, Jagesh V. ;

Cleveland, Don W. .

MOLECULAR CELL, 2007, 25 (02) :309-322

[7] Conserved organization of centromeric chromatin in flies and humans [J].

Blower, MD ;

Sullivan, BA ;

Karpen, GH .

DEVELOPMENTAL CELL, 2002, 2 (03) :319-330

[8] Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a functional kinetochore [J].

Camahort, Raymond ;

Li, Bing ;

Florens, Laurence ;

Swanson, Selene K. ;

Washburn, Michael P. ;

Gerton, Jennifer L. .

MOLECULAR CELL, 2007, 26 (06) :853-865

[9] Cse4 Is Part of an Octameric Nucleosome in Budding Yeast [J].

Camahort, Raymond ;

Shivaraju, Manjunatha ;

Mattingly, Mark ;

Li, Bing ;

Nakanishi, Shima ;

Zhu, Dongxiao ;

Shilatifard, Ali ;

Workman, Jerry L. ;

Gerton, Jennifer L. .

MOLECULAR CELL, 2009, 35 (06) :794-805

[10] Dual recognition of CENP-A nucleosomes is required for centromere assembly [J].

Carroll, Christopher W. ;

Milks, Kirstin J. ;

Straight, Aaron F. .

JOURNAL OF CELL BIOLOGY, 2010, 189 (07) :1143-1155

← 1 2 3 4 5 6 →