Epigenetic Centromere Propagation and the Nature of CENP-A Nucleosomes

被引：267

作者：

Black, Ben E. ^{[1
]}

Cleveland, Don W. ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Univ Calif San Diego, Ludwig Inst Canc Res, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

CELL | 2011年 / 144卷 / 04期

基金：

美国国家卫生研究院;

关键词：

E3 UBIQUITIN LIGASE; FISSION YEAST SCM3; HISTONE H3 VARIANT; CHROMATIN REQUIRES; MAINTENANCE; DOMAIN; CSE4; ORGANIZATION; REPLICATION; RECOGNITION;

D O I：

10.1016/j.cell.2011.02.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Centromeres direct chromosome inheritance, but in multicellular organisms their positions on chromosomes are primarily specified epigenetically rather than by a DNA sequence. The major candidate for the epigenetic mark is chromatin assembled with the histone H3 variant CENP-A. Recent studies offer conflicting evidence for the structure of CENP-A-containing chromatin, including the histone composition and handedness of the DNA wrapped around the histones. We present a model for the assembly and deposition of centromeric nucleosomes that couples these processes to the cell cycle. This model reconciles divergent data for CENP-A-containing nucleosomes and provides a basis for how centromere identity is stably inherited.

引用

页码：471 / 479

页数：9

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