A method for the quantification of resin loading using 19F gel phase NMR spectroscopy and a new method for benzyl ether linker cleavage in solid phase chemistry.

被引：41

作者：

Stones, D

Miller, DJ

Beaton, MW

Rutherford, TJ

Gani, D

机构：

[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland

[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)00883-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method for monitoring and quantifying the extent of loading onto polymer resin supports for solid-phase synthesis using F-19 gel-phase NMR spectroscopy is described. This assay was utilised in the synthesis of an inositol monophosphatase inhibitor on Merrifield resin. A series of Merrifield resin derived benzylic ethers were prepared and were cleaved from the resin when treated with SnCl4 at room temperature to give the expected alcohol, phenol or olefin. This new cleavage method was used to remove the inositol monophosphatase inhibitor from the resin. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4875 / 4878

页数：4

共 13 条

[1]

BEATON MW, UNPUB

[2] High throughput on-bead monitoring of solid phase reactions by diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) [J].