The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation

被引：107

作者：

Chevet, E ^{[1
]}

Cameron, PH

Pelletier, MF

Thomas, DY

Bergeron, JJM

机构：

[1] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2B2, Canada

[2] McGill Univ, Dept Biochem, Montreal, PQ H3A 2B2, Canada

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(00)00168-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function as an integrated mechanism. The creation of such a molecular network, spatially regulated, suggests how the endoplasmic reticulum promotes the release of correctly folded secretory proteins.

引用

页码：120 / 124

页数：5

共 47 条

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