The CD1 family of lipid antigen-presenting molecules

被引：117

作者：

Porcelli, SA

Segelke, BW

Sugita, M

Wilson, IA

Brenner, MB

机构：

[1] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Univ Calif Lawrence Livermore Natl Lab, Dept Macromol Crystallog, Livermore, CA 94551 USA

[4] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[5] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(98)01289-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The paradigm that T cells recognize peptide antigens presented by major histocompatibility complex class I and class II molecules has been a guiding principle in the development of immunology. Here, Steven Porcelli and colleagues review studies that extend this paradigm by showing that CD1 proteins are a separate lineage of antigen-presenting molecules with unusually hydrophobic ligand-binding grooves that present nonpeptide lipid and glycolipid antigens to T cells.

引用

页码：362 / 368

页数：7

共 60 条

[1] SENSITIVE AND HIGH-RESOLUTION INSITU HYBRIDIZATION TO HUMAN-CHROMOSOMES USING BIOTIN LABELED PROBES - ASSIGNMENT OF THE HUMAN THYMOCYTE CD1 ANTIGEN GENES TO CHROMOSOME-1 [J].