RanBPM is a novel binding protein for p75NTR

被引：41

作者：

Bai, D

Chen, H

Huang, BR ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem & Mol Biol, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 309卷 / 03期

基金：

中国国家自然科学基金;

关键词：

RanBPM; signal transduction; p75NTR;

D O I：

10.1016/j.bbrc.2003.08.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The neurotrophin receptor p75NTR can induce signal transduction both in vivo and in vitro. The mechanisms by which p75NTR transduces signals have remained mostly unknown. Using yeast two-hybrid system, we identified the Ran-binding protein (Ran-BPM) as an interactor with the intracytoplasmic domain of p75NTR (p75ICD). The interaction was then validated by immunoprecipitation in mammalian cells and immunoblotting analysis. The domain in p75ICD interacting with RanBPM was mapped to the death domain. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：552 / 557

页数：6

共 36 条

[1] MITOTIC REGULATOR PROTEIN RCC1 IS COMPLEXED WITH A NUCLEAR RAS-RELATED POLYPEPTIDE [J].

BISCHOFF, FR ;

PONSTINGL, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10830-10834

[2]

BONNEFIL PC, 1996, NATURE, V383, P716

[3]

Bronfman FC, 2003, J NEUROSCI, V23, P3209

[4] Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75 [J].

Carter, BD ;

Kaltschmidt, C ;

Kaltschmidt, B ;

Offenhauser, N ;

BohmMatthaei, R ;

Baeuerle, PA ;

Barde, YA .

SCIENCE, 1996, 272 (5261) :542-545

[5] The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death [J].

Casademunt, E ;

Carter, BD ;

Benzel, I ;

Frade, JM ;

Dechant, G ;

Barde, YA .

EMBO JOURNAL, 1999, 18 (21) :6050-6061

[6] THE P75 NEUROTROPHIN RECEPTOR [J].

CHAO, MV .

JOURNAL OF NEUROBIOLOGY, 1994, 25 (11) :1373-1385

[7] Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor [J].

Chittka, A ;

Chao, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10705-10710

[8] Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death [J].

Coulson, EJ ;

Reid, K ;

Baca, M ;

Shipham, KA ;

Hulett, SM ;

Kilpatrick, TJ ;

Bartlett, PF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (39) :30537-30545

[9] Signalling through the neurotrophin receptor p75(NTR) [J].

Dechant, G ;

Barde, YA .

CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) :413-418

[10] ACTIVATION OF THE SPHINGOMYELIN CYCLE THROUGH THE LOW-AFFINITY NEUROTROPHIN RECEPTOR [J].

DOBROWSKY, RT ;

WERNER, MH ;

CASTELLINO, AM ;

CHAO, MV ;

HANNUN, YA .

SCIENCE, 1994, 265 (5178) :1596-1599

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