Pharmacokinetics using fluorine NMR in vivo

被引:55
作者
Bachert, P [1 ]
机构
[1] Deutsch Krebsforschungszentrum, Abt Med Phys & Biophys, Forsch Schwerpunkt Radiol Diagnost & Therapie, D-60120 Heidelberg, Germany
关键词
fluorine; in vivo F-19 NMR spectroscopy; chemical-shift imaging; double resonance; dynamic nuclear polarization; nuclear Overhauser effect; spin decoupling; 5-fluorouracil; alpha-fluoro-beta-alanine; metabolism; pharmacokinetics; kinetic modeling; nonlinear compartment model; drug monitoring; chemotherapy; liver tumor;
D O I
10.1016/S0079-6565(98)00016-8
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1 / 56
页数:56
相关论文
共 186 条
[91]   INVIVO NMR-SPECTROSCOPY OF LI-7 IN HUMANS [J].
KOMOROSKI, RA ;
NEWTON, JEO ;
WALKER, E ;
CARDWELL, D ;
JAGANNATHAN, NR ;
RAMAPRASAD, S ;
SPRIGG, J .
MAGNETIC RESONANCE IN MEDICINE, 1990, 15 (03) :347-356
[92]   DETECTION OF PSYCHOACTIVE-DRUGS INVIVO IN HUMANS USING F-19 NMR-SPECTROSCOPY [J].
KOMOROSKI, RA ;
NEWTON, JEO ;
KARSON, C ;
CARDWELL, D ;
SPRIGG, J .
BIOLOGICAL PSYCHIATRY, 1991, 29 (07) :711-714
[93]  
KOUTCHER JA, 1988, 7TH P ANN M SOC MAGN, P329
[94]   F-19-(H-1) NUCLEAR OVERHAUSER EFFECT AND PROTON DECOUPLING OF 5-FLUOROURACIL AND ALPHA-FLUORO-BETA-ALANINE [J].
KREMS, B ;
BACHERT, P ;
ZABEL, HJ ;
LORENZ, WJ .
JOURNAL OF MAGNETIC RESONANCE SERIES B, 1995, 108 (02) :155-164
[95]  
KREMS B, 1994, 2 ANN SCI M SOC MAGN, P1163
[96]   NMR FOURIER ZEUGMATOGRAPHY [J].
KUMAR, A ;
WELTI, D ;
ERNST, RR .
JOURNAL OF MAGNETIC RESONANCE, 1975, 18 (01) :69-83
[97]   ZEUGMATOGRAPHIC HIGH-RESOLUTION NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - IMAGES OF CHEMICAL INHOMOGENEITY WITHIN MACROSCOPIC OBJECTS [J].
LAUTERBUR, PC ;
KRAMER, DM ;
HOUSE, WV ;
CHEN, CN .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (23) :6866-6868
[98]   COMPOSITE PULSE DECOUPLING [J].
LEVITT, MH ;
FREEMAN, R .
JOURNAL OF MAGNETIC RESONANCE, 1981, 43 (03) :502-507
[99]   Simultaneous 3D NMR spectroscopy of fluorine and phosphorus in human liver during 5-fluorouracil chemotherapy [J].
Li, CW ;
Gonen, O .
MAGNETIC RESONANCE IN MEDICINE, 1996, 35 (06) :841-847
[100]  
Li CW, 1996, CLIN CANCER RES, V2, P339