Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

被引：235

作者：

Wallingford, John B. ^{[1
]}

Mitchell, Brian ^{[2
]}

机构：

[1] Univ Texas Austin, Howard Hughes Med Inst, Sect Mol Cell & Dev Biol, Inst Cellular & Mol Biol, Austin, TX 78712 USA

[2] Northwestern Univ, Dept Cell & Mol Biol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 03期

关键词：

cilia; Wnt signaling; planar cell polarity; basal bodies; diffusion barriers; ciliary pores; IFT; NEURAL-TUBE CLOSURE; INTRAFLAGELLAR TRANSPORT PROTEINS; CONVERGENT EXTENSION MOVEMENTS; BARDET-BIEDL-SYNDROME; SUBCELLULAR-LOCALIZATION; INNER-EAR; VERTEBRATE GASTRULATION; EMBRYONIC-DEVELOPMENT; RETINAL DEGENERATION; PRIMARY CILIOGENESIS;

D O I：

10.1101/gad.2008011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/beta-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.

引用

页码：201 / 213

页数：13

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