The role of calmodulin kinase II in myocardial physiology and disease

被引：104

作者：

Couchonnal, Luis F. ^{[1
]}

Anderson, Mark E. ^{[1
]}

机构：

[1] Univ Iowa, Dept Internal Med, Div Cardiovasc Med, Carver Coll Med, Iowa City, IA 52242 USA

来源：

PHYSIOLOGY | 2008年 / 23卷 / 03期

关键词：

D O I：

10.1152/physiol.00043.2007

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The multifunctional Ca2+/calmodulin- dependent protein kinase II ( CaMKII) regulates a rich variety of downstream targets in heart. Ca2+ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

引用

页码：151 / 159

页数：9

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