Surface modification of hydroxyapatite nanoparticles by poly(L-phenylalanine) via ROP of L-phenylalanine N-carboxyanhydride (Pha-NCA)

被引：27

作者：

Dai, Yanfeng ^{[1
]}

Xu, Min ^{[1
]}

Wei, Junchao ^{[1
]}

Zhang, Haobin ^{[1
]}

Chen, Yiwang ^{[1
]}

机构：

[1] Nanchang Univ, Dept Chem, Nanchang 330031, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2012年 / 258卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Hydroxyapatite; Surface modification; Ring opening polymerization; Bone tissue engineering; GRAFTING POLYMERIZATION; MECHANICAL-PROPERTIES; NANO-CRYSTALS; COMPOSITES; ACID; AGENTS; BIOCOMPATIBILITY; POLY(L-LACTIDE); PARTICLES; POWDERS;

D O I：

10.1016/j.apsusc.2011.10.147

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The surface of hydroxyapatite nanoparticles was modified by poly(L-phenylalanine) via the ring opening polymerization (ROP) of L-phenylalanine N-carboxyanhydride. The preparation procedure was monitored by Fourier transform infrared spectroscopy (FTIR), and the modified hydroxyapatite was characterized by thermal gravimetric analysis (TGA) and X-ray diffraction (XRD). The results showed that the surface grafting amounts of poly(l-phenylalanine) on HA ranging from 20.26% to 38.92% can be achieved by tuning the reaction condition. The XRD patterns demonstrated that the crystalline structure of the modified hydroxyapatite was nearly the same with that of HA, implying that the ROP was an efficient surface modification method. The MTT assay proved that the biocompatibility of modified HA was very good, which showed the potential application of modified HA in bone tissue engineering. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：2850 / 2855

页数：6

共 28 条

[1]

Surface modification of hydroxyapatite nanocrystals by grafting polymers containing phosphonic acid groups [J].