Biocompatibility screening of silane-treated hydroxyapatite powders, for use as filler in resorbable composites

被引：52

作者：

Dupraz, AMP ^{[1
]}

vandenMeer, SAT ^{[1
]}

DeWijn, JR ^{[1
]}

Goedemoed, JH ^{[1
]}

机构：

[1] HC IMPLANTS BV, NL-2333 CK LEIDEN, NETHERLANDS

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1996年 / 7卷 / 12期

关键词：

D O I：

10.1007/BF00121408

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study reports in vitro biocompatibility screening of different kinds of silane-treated hydroxyapatite (HA) powders, for use as modified filler in resorbable composite. The silane coupling agents investigated were all methoxysilanes, with either vinyl (VS), or methacryloxy (MPS), or primary amine (AMMO), or secondary amine (TRIAMO), or diamine (DAS) functionality. Evaluation of cell adhesion on the different silanized HA surfaces, indirect agar-overlay test and direct contact test on extracts showed the acute toxicity of all five free silane agents, the innocuity of strongly adsorbed silane molecules on HA surfaces and the dose-dependent toxicity of leachable silanol molecules.

引用

页码：731 / 738

页数：8

共 20 条

[1] BIOCOMPATIBILITY AND MECHANICAL-PROPERTIES OF A TOTALLY ABSORBABLE COMPOSITE-MATERIAL FOR ORTHOPEDIC FIXATION DEVICES [J].