Induction of TrkA receptor by retinoic acid in leukaemia cell lines

被引：23

作者：

Xie, P ^{[1
]}

Cheung, WMW ^{[1
]}

Ip, FCF ^{[1
]}

Ip, NY ^{[1
]}

Leung, MF ^{[1
]}

机构：

[1] HONG KONG UNIV SCI & TECHNOL,DEPT BIOL,KOWLOON,HONG KONG

来源：

NEUROREPORT | 1997年 / 8卷 / 05期

关键词：

leukemia differentiation; neurotrophic factor receptors; neurotrophic factors; retinoic acid;

D O I：

10.1097/00001756-199703240-00001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To explore the potential involvement of neurotrophins in the actions of retinoic acid (RA) on leukaemia differentiation, we examined the ability of RA to regulate the expression of neurotrophins and Trk receptors in several leukaemia cell lines. Expression of TrkA was dramatically induced by RA at both the mRNA and protein level in leukaemia cell lines K562 and KG-1. Furthermore, while no expression of trkB and trkC was detected, constitutive expression of nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 could be detected in leukemia cells. Our findings suggested that NGF/trkA may potentially be involved in the RA-induced differentiation of leukemia cells.

引用

页码：1067 / 1070

页数：4