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Anti-tumor necrosis factor-α monoclonal antibody therapy for rheumatoid arthritis

被引：66
作者：
Kavanaugh, AF
机构：
[1] Univ Texas, SW Med Sch, Dallas, TX 75235 USA
[2] Vet Adm N Texas Hlth Care Syst, Dallas, TX USA
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 1998年 / 24卷 / 03期
关键词：
D O I：
10.1016/S0889-857X(05)70028-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Because it plays a central role in the immunopathogenesis of rheumatoid arthritis (RA), TNF-alpha is an attractive target for immunomodulatory therapy. In a number of rigorous studies, monoclonal antibodies (mAb) specific for TNF-alpha have proved efficacious in patients with active RA. Data from these studies and issues related to mechanisms of action, potential toxicity, and future directions for this novel therapeutic approach are considered in this review.
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收藏
页码：593 / +
页数：23
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