Evaluation of focal cerebral ischemia in rats by magnetic resonance imaging and immunohistochemical analyses

被引：14

作者：

Ishii, H

Arai, T ^{[1
]}

Morikawa, S

Inubushi, T

Tooyama, I

Kimura, H

Mori, K

机构：

[1] Kyoto Univ Hosp, Dept Anesthesia, Sakyo Ku, Kyoto 606, Japan

[2] Shiga Univ Med Sci, Mol Neurol Res Ctr, Shiga, Japan

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1998年 / 18卷 / 09期

关键词：

focal cerebral ischemia; magnetic resonance imaging immunohistochemistry; middle cerebral artery occlusion; rats;

D O I：

10.1097/00004647-199809000-00001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Correlation of focal ischemia-induced brain damage evidenced by magnetic resonance imaging (MRI) and by staining with microtubule-associated protein 2 (MAP2) was studied in rats. Ischemia was produced by transient occlusion of the middle cerebral artery (MCAO). The damage was assessed at 6 to 8 hours after MCAO and 1 week later. The area of damage assessed by MRI agreed with that by MAP2 staining at 6 to 8 hours after MCAO, which was smaller (P < 0.001) than that defined by MAP2 staining 1 week after MCAO. Glial staining indicated that glial infiltration affected the signal intensity of MRI in the area of damage.

引用

页码：931 / 934

页数：4

共 9 条

[1] QUANTITATIVE COMPARISON OF MAGNETIC-RESONANCE-IMAGING (MRI) AND HISTOLOGIC ANALYSES OF FOCAL ISCHEMIC DAMAGE IN THE RAT [J].