Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions

被引:235
作者
Barrila, Jennifer [1 ]
Radtke, Andrea L. [1 ]
Crabbe, Aurelie [1 ]
Sarker, Shameema F. [1 ]
Herbst-Kralovetz, Melissa M. [1 ,2 ]
Ott, C. Mark [3 ]
Nickerson, Cheryl A. [1 ]
机构
[1] Arizona State Univ, Sch Life Sci, Biodesign Inst, Ctr Infect Dis & Vaccinol, Tempe, AZ 85287 USA
[2] Univ Arizona, Coll Med Phoenix, Dept Basic Med Sci, Phoenix, AZ 85004 USA
[3] NASA, Habitabil & Environm Factors Div, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA
基金
美国国家航空航天局; 美国国家卫生研究院;
关键词
ENTERICA SEROVAR TYPHIMURIUM; EPITHELIAL-CELLS; SIMULATED MICROGRAVITY; INNATE IMMUNITY; IN-VITRO; INTESTINAL EPITHELIUM; 3-DIMENSIONAL CULTURE; EXTRACELLULAR-MATRIX; SALMONELLA-TYPHIMURIUM; TISSUE ARCHITECTURE;
D O I
10.1038/nrmicro2423
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学];
摘要
Appropriately simulating the three-dimensional (3D) environment in which tissues normally develop and function is crucial for engineering in vitro models that can be used for the meaningful dissection of host-pathogen interactions. This Review highlights how the rotating wall vessel bioreactor has been used to establish 3D hierarchical models that range in complexity from a single cell type to multicellular co-culture models that recapitulate the 3D architecture of tissues observed in vivo. The application of these models to the study of infectious diseases is discussed.
引用
收藏
页码:791 / 801
页数:11
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