Microenvironmental control of premalignant disease: the role of intercellular adhesion in the progression of squamous cell carcinoma

被引：32

作者：

Alt-Holland, A ^{[1
]}

Zhang, WT ^{[1
]}

Margulis, A ^{[1
]}

Garlick, JA ^{[1
]}

机构：

[1] Tufts Univ, Sch Dent Med, Dept Oral Pathol, Div Canc Biol & Tissue Engn, Medford, MA 02155 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 02期

关键词：

cell-cell interactions; intraepithelial neoplasia; premalignant disease; squamous cell cancer; E-cadherin; basement membrane;

D O I：

10.1016/j.semcancer.2004.08.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interactions between potentially neoplastic cells and their normal neighbors act as an important microenvironmental control during the premalignant, intraepithelial (IE) stage of squamous cell cancer development. Using human three-dimensional (3D) tissue models, it has been shown that such interactions induce a state of IE dormancy in which cancer progression is suppressed. This dormant state can be overcome by altering tissue dynamics in response to the tumor promoter TPA, UV irradiation, decreasing adhesive interactions between tumor cells and adjacent epithelia or enabling tumor cells to interact with basement membrane proteins. This chapter will provide an overview of investigations that have characterized how the tissue microenvironment can regulate the incipient development of squamous cell carcinoma. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：84 / 96

页数：13

共 55 条

[1] TRANSGENIC MODELS OF TUMOR-DEVELOPMENT [J].

ADAMS, JM ;

CORY, S .

SCIENCE, 1991, 254 (5035) :1161-1167

[2] Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases [J].

Andrews, NA ;

Jones, AS ;

Helliwell, TR ;

Kinsella, AR .

BRITISH JOURNAL OF CANCER, 1997, 75 (10) :1474-1480

[3] Analysis of microenvironmental factors contributing to basement membrane assembly and normalized epidermal phenotype [J].

Andriani, F ;

Margulis, A ;

Lin, N ;

Griffey, S ;

Garlick, JA .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (06) :923-931

[4]

[Anonymous], J INVESTIG DERMATOL

[5] E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium [J].

Auersperg, N ;

Pan, J ;

Grove, BD ;

Peterson, T ;

Fisher, J ;

Maines-Bandiera, S ;

Somasiri, A ;

Roskelley, CD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) :6249-6254

[6]

Bagutti C, 1998, J PATHOL, V186, P8, DOI 10.1002/(SICI)1096-9896(199809)186:1<8::AID-PATH156>3.0.CO

[7]

2-H

[8] Cadherins and catenins: Role in signal transduction and tumor progression [J].

Behrens, J .

CANCER AND METASTASIS REVIEWS, 1999, 18 (01) :15-30

[9]

Bindels EMJ, 2000, CANCER RES, V60, P177

[10] CADHERIN EXPRESSION IN CARCINOMAS - ROLE IN THE FORMATION OF CELL-JUNCTIONS AND THE PREVENTION OF INVASIVENESS [J].

BIRCHMEIER, W ;

BEHRENS, J .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01) :11-26

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