Microenvironmental control of premalignant disease: the role of intercellular adhesion in the progression of squamous cell carcinoma

被引：32

作者：

Alt-Holland, A ^{[1
]}

Zhang, WT ^{[1
]}

Margulis, A ^{[1
]}

Garlick, JA ^{[1
]}

机构：

[1] Tufts Univ, Sch Dent Med, Dept Oral Pathol, Div Canc Biol & Tissue Engn, Medford, MA 02155 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 02期

关键词：

cell-cell interactions; intraepithelial neoplasia; premalignant disease; squamous cell cancer; E-cadherin; basement membrane;

D O I：

10.1016/j.semcancer.2004.08.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interactions between potentially neoplastic cells and their normal neighbors act as an important microenvironmental control during the premalignant, intraepithelial (IE) stage of squamous cell cancer development. Using human three-dimensional (3D) tissue models, it has been shown that such interactions induce a state of IE dormancy in which cancer progression is suppressed. This dormant state can be overcome by altering tissue dynamics in response to the tumor promoter TPA, UV irradiation, decreasing adhesive interactions between tumor cells and adjacent epithelia or enabling tumor cells to interact with basement membrane proteins. This chapter will provide an overview of investigations that have characterized how the tissue microenvironment can regulate the incipient development of squamous cell carcinoma. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：84 / 96

页数：13

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